Action YEAR 3
Specific objectives, activities, deliverables
Working Group 1
Objective 1: Summarize local knowledge on taeniosis/cysticercosis epidemiology
- Activity 1.1. Perform search in local data sources based on Country Sheets
- Activity 1.2. Finalize and submit review paper Western Europe
- Activity 1.4. Initiate in-depth studies on local epidemiology of taeniosis/cysticercosis in specific countries
- Deliverable 1.1. Summary of local data
- Deliverable 1.2. Submitted review paper Western Europe
- Deliverable 1.3. Submitted review paper Eastern Europe
- Deliverable 1.4. Procedures developed
Objective 2: Review existing Taenia spp. transmission models
- Activity 2.1. Carry out a review on existing Taenia spp transmission models
- Deliverable 2.1. Submitted review paper on Taenia spp. transmission models
Objective 3: Improve the T. solium transmission model and develop a T. saginata transmission model
- Activity 3.1. Develop the T. saginata diseases transmission model, based on T. solium model
- Deliverable 3.1. Submitted manuscript on Taenia saginata transmission model
Objective 4: Initiate case studies on Taenia saginata health and economic impact
- Activity 4.1a. Case studies on Taenia saginata economic impact
- Activity 4.1b. Case studies on Taenia saginata health impact
- Activity 4.2. Task force meeting on Taenia saginata health and economic impact
- Activity 4.3. Asses economic impact of Bovine cysticercosis in European Union
- Deliverable 4.1. Taenia saginata burden assessments initiated in at least one country
- Deliverable 4.2. Task force meeting minutes
- Deliverable 4.3. Procedures developed
Objective 5: Extend the network of stakeholders involved in Taenia spp epidemiological research, with a focus on inclusiveness countries
- Activity 5.1. Actively seek to involve other researchers in the epidemiology field (focus on inclusiveness countries)
- Deliverable 5.1: increased nr of WG1 members, with a focus on inclusiveness countries
Objective 6. Facilitate molecular confirmation of PCC
- Activity 6.1. Further promote molecular confirmation suspected lesion
- Deliverable 6.1. Up to date list of molecular confirmation capacity
Objective 7. Study epidemiology of Taenia saginata at global level
- Activity 7.1. Review global occurrence of Taenia saginata taeniosis/cysticercosis
- Deliverable 7.1. Procedures developed
Objective 8. Develop regional and global Taenia spp. risk maps
- Activity 8.1. Initiate review on risk of T. solium in Central America
- Deliverable 8.1. Procedures developed
Working Group 2
Objective 1: Evaluation of human & animal diagnosis questionnaire in the participating countries
- Activity 1.1 update list of diagnostics performed, update the map from WG1 with info from this list
- Activity 1.2 Writing of diagnostic review
- Activity 1.3 Presentation of T/CC facilities and performed tests in different countries and asking for permission to make this information publicly available
- Deliverable 1.1 Updated list as part of the diagnostic review
- Deliverable 1.2 Submission of final draft of diagnostic review
- Deliverable 1.3 Updated list and circulation of that list among Cystinet members
- Deliverable 1.4 Updated map and publication of it on the Cystinet website
Objective 2: Evaluation of the inter-laboratory ring trial on serological detection of NCC
- Activity 2.4.Ring trial report: lab performances, gap analyses and recommendations
- Deliverable 2.4. Writing of recommendations for NCC serological diagnosis
Objective Extension 2b: Organization of an inter-laboratory ring trial on coprological detection for T diagnosis
- Activity 2b.1. Design of an inter-laboratory ring trial for T diagnosis based on coprological detection
- Activity 2b.2. Establishment of a panel of samples, including feces, positives and negatives for taeniasis (T. sag/T. sol).
- Activity 2b.3. Distribution of selected samples to the participating labs
- Activity 2b.4. Evaluation of diagnosis ring-trial data
- Deliverable 2b.1. Protocol established
- Deliverable 2b.2. Panels of samples established (list)
- Deliverable 2b3. shipment list
- Deliverable 2b.4. RT Report
Objective 2c: ESTABLISHMENT OF Disease-BIOMARKERS (Glycome)
- Activity 2c.1. Determination of glycome differences among the distinct NCC types (Extraparenchymal vs parenchymanl, active vs inactive;…)
- Activity 2c.2.IgG glycosilation profiles from different NCC types (Extraparenchymal vs parenchymanl, active vs inactive;…)
- Deliverable 2c.1. Draft report
- Deliverable 2c.2. draft report
- Deliverable 2c.3. Writing of differences found on glycome profiles of patients with different forms of NCC (Publication)
Objective 3: Data bank of Taenia molecules with diagnosis potential, described by the different labs based on -omics approaches and bioinformatic analyses
- Activity 3.1. Compilation of molescules identified and used for T/NCC diagnosis in European Labs.
- Activity 3.1. Distribution of information to European Labs
- Deliverables 3.1. Publication by end 2017
Objective 4: Extend the network of stakeholders involved in Taenia spp diagnostics and fundamental research, with a focus on inclusiveness countries
- Deliverable 4.1 Increased number of WG members
Objective 5: Formal assessment of the prevalence of NCC and its clinical characteristics in Europe and overseas departments (continued form year 1)
- Deliverable 5.1. Writing up and submission of the mansucript
Objective 6: Exploring ways of a European registry TSCT/NCC (in collaboration with WP1)
- Activity 6.1. Assess willingness of European partrners to contribute
- Activity 6.2. Assess funding possibilities: to year 4
- Deliverable 6.1. Provide a list of countries willing to contribute: done: none of the countries
- Deliverable .6.2. Provide a list of funding possibilities: to Y4
Objective 7: Exploring ways of establishing a EU wide mandatry reporting system for NCC (in collaboration with WP1)
- Activity 7.1 Drafting of position paper
- Deliverable 7.1 Submission of position paper
Objective 8: Collection of case reports of partner countries on NCC management
- Deliverable 8.1 Documentation of follow up of cases
Objective 9: Establishment of informal guidelines for NCC management in Europe
- Activity 9.1. establishment of task force: done
- Activity 9.2 Development of step-by-step approach to NCC diagnosis and management
- Activity 9.3 Organisation of second task force meeting
- Deliverable 9.1 final task force meeting 1 report
- Deliverable 9.2 Report of guidelines
- Deliverable 9.3 Task force report
Working Group 3
Objective 1: Assess control tools and algoritms for best bet options
- Deliverable 1.1: Opinion note on ‘best-bet’ option for control for endemic countries selected by WHO/FAO/OIE
- Deliverable 1.2: Publication on intervention tools for control of Taenia solium cysticercosis elimination in sub-Saharan Africa (Parasitology – submitted)
- Deliverable 1.3: CystiSim – an agent-based model for Taenia solium transmission and control (shared with WP1)
- Deliverable 1.4: The societal cost of Taenia solium cysticercosis in Tanzania (Acta Tropica, Special edition – in press). (shared with WP1)
- Deliverable 1.5: Review – Added value of MDAs (human focus)
- Deliverable 1.6: Opinion note on “the step-wise approach” for the control
Objective 2: Collect data from pilot control programs from endemic areas and look into adaptation to EU conditions
- Deliverable 2.1: Review – T. saginata Globally (coordinated with WG1)
- Deliverable 2.2: Review – Effectiveness of Taenia control programmes, preliminary draft
- Deliverable 2.3: Cystinet Blue print (start of document)
- Deliverable 2.4: Occurrence of other Taenia spp in the EU: Draft manuscript
Objective 3: Extend the network of stakeholders involved in Taenia prevention and control to establish a multidisciplinary working group
- Link with WHO/FAO/OIE informal T. solium network
- link with EFSA
- Link with other sectors (water & sanitation, e.g. World Water Forum etc.), continue seeking collaboration with relevant stakeholders
- Link with ECDC
- Link with the European College of Veterinary Public Health
- Link with the parasitology college (bring CYSTINET to Bari 2016)
Objective 4: Collect data from control programs for T. saginata /T. solium in Europe
- Paper – data on diagnostic techniques for bovine cysticercosis, model for cost in EU
- Paper – bovine cysticercosis including meat regulation and current projects on control for T. saginata in bovine
Objective 5: collect data on home slaughetering via QS
- View point – home slaughtering regulations
Objective 6: Study the presence and survival of Taenia eggs in the environment
- Review – survival of Taenia in the environment
- MSc + publication – in vitro testing of T. saginata
Objective 7: To identify existing reporting/ surveillance systems for cysticercosis/ taeniosis in EU
- Report – how to make a disease (Taeniosis / NCC) notifiable
- Report – Country specific regulations for health check of refugees/immigrants + health certificates
- Short communication to Euro surveillance + local GP (coordinated with WG1 &WG2)